计算机科学
DNA折纸
曲率
纳米结构
渡线
纳米技术
算法
材料科学
人工智能
数学
几何学
作者
Daniel Fu,Raghu Pradeep Narayanan,Abhay Prasad,Shirong Wang,Dewight Williams,John S. Schreck,Hao Yan,John H. Reif
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-12-23
卷期号:8 (51)
被引量:1
标识
DOI:10.1126/sciadv.ade4455
摘要
Improving the precision and function of encapsulating three-dimensional (3D) DNA nanostructures via curved geometries could have transformative impacts on areas such as molecular transport, drug delivery, and nanofabrication. However, the addition of non-rasterized curvature escalates design complexity without algorithmic regularity, and these challenges have limited the ad hoc development and usage of previously unknown shapes. In this work, we develop and automate the application of a set of previously unknown design principles that now includes a multilayer design for closed and curved DNA nanostructures to resolve past obstacles in shape selection, yield, mechanical rigidity, and accessibility. We design, analyze, and experimentally demonstrate a set of diverse 3D curved nanoarchitectures, showing planar asymmetry and examining partial multilayer designs. Our automated design tool implements a combined algorithmic and numerical approximation strategy for scaffold routing and crossover placement, which may enable wider applications of general DNA nanostructure design for nonregular or oblique shapes.
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