药物输送到大脑
微气泡
血脑屏障
医学
药物输送
纳米医学
药品
聚焦超声
脑病
疾病
药理学
神经科学
超声波
病理
中枢神经系统
内科学
纳米技术
心理学
放射科
材料科学
纳米颗粒
作者
Jieqiong Wang,Zhenzhou Li,Min Pan,Muhammad Fiaz,Yongsheng Hao,Yiran Yan,Litao Sun,Fei Yan
标识
DOI:10.1016/j.addr.2022.114539
摘要
Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases. Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently open the BBB, providing a potential strategy for drug delivery across the BBB into the brain. Nowadays, taking advantage of this technology, many therapeutic agents, such as antibodies, growth factors, and nanomedicine formulations, are intensively investigated across the BBB into specific brain regions for the treatment of various brain diseases. Several preliminary clinical trials also have demonstrated its safety and good tolerance in patients. This review gives an overview of the basic mechanisms, ultrasound contrast agents, evaluation or monitoring methods, and medical applications of FUS-mediated BBB opening in glioblastoma, Alzheimer's disease, and Parkinson's disease.
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