Polygenic Susceptibility to Diabetes and Poor Glycemic Control in Stroke Survivors

BACKGROUND AND OBJECTIVES: Type 2 diabetes mellitus (T2DM) is highly genetically determined, and polygenic susceptibility to T2DM (PSD) increases the risk of worse glycemic control and adverse vascular outcomes. Its role in stroke patients remains unknown. We aim to determine whether higher PSD is associated with worse glycemic control in stroke survivors. METHODS: ). Outcomes were hemoglobin A1c (HbA1c) levels, uncontrolled diabetes (HbA1c ≥7.0%), and resistant diabetes (uncontrolled despite antidiabetic treatment). RESULTS: -trend <0.05 for all tests). DISCUSSION: Among stroke survivors, a higher PSD was associated with poorer glycemic control. Further research should determine precision medicine strategies using PSD to improve clinical management of stroke patients.