The Clinical Relevance of FTO as a Demethylase Beyond Cancer: Molecular Mechanisms and Therapeutic Opportunities

A), thereby influencing RNA splicing, stability, and translation. This regulatory activity plays a major role in processes such as inflammation and fibrosis. Dysregulation of FTO has been implicated in several non-malignant diseases, including metabolic disorders, neurological diseases, and cardiovascular conditions. Computational docking studies showed that FTO exhibited strong binding affinity with two drugs and moderate affinity with eight others. Bibliometric analysis revealed high-frequency keywords and visualized research hotspots pertaining to FTO, providing valuable insight into current areas of scientific interest and potential future directions of study. FTO functions as a key epigenetic regulator in non-cancerous diseases and represents a promising biomarker and therapeutic target. Our findings underscore the importance of FTO-drug interactions and suggest that small-molecule FTO modulators may hold therapeutic value for managing a variety of non-oncologic conditions.