简明精神病评定量表
精神分裂症(面向对象编程)
内科学
尿酸
认知
医学
人口
延迟(音频)
评定量表
胃肠病学
精神科
心理学
精神病
听力学
发展心理学
环境卫生
电气工程
工程类
作者
Wen Hu,Bing-shu Cheng,Lei Su,J. Lv,Jiajia Zhu
标识
DOI:10.1016/j.encep.2023.01.006
摘要
We explored the relationship between levels of serum uric acid (UA) and cognitive impairment in people with schizophrenia to order to better protect and improve cognitive function in such patients.A uricase method evaluated serum UA levels in 82 individuals with first-episode schizophrenia and in 39 healthy controls. The Brief Psychiatric Rating Scale (BPRS) and the event-related potential P300 were used to assess the patient's psychiatric symptoms and cognitive functioning. The link between serum UA levels, BPRS scores, and P300 was investigated.Prior to treatment, serum UA levels and latency N3 in the study group were significantly higher than in the control group, whereas the amplitude P3 was considerably lower. After therapy, the study group's BPRS scores, serum UA levels, latency N3, and amplitude P3 were lower than before treatment. According to correlation analysis, serum UA levels in the pre-treatment study group significantly positively correlated with BPRS score and latency N3 but not amplitude P3. After therapy, serum UA levels were no longer substantially related to the BPRS score or amplitude P3 but strongly and positively correlated with latency N3.First-episode schizophrenia patients have higher serum UA levels than the general population which partly reflects poor cognitive performance. Improving patients' cognitive function may be facilitated by lowering serum UA levels.
科研通智能强力驱动
Strongly Powered by AbleSci AI