千叶阿喀琉亚
化学
倍半萜
圆二色性
立体化学
一氧化氮
碳-13核磁共振
二维核磁共振波谱
有机化学
传统医学
医学
作者
Hongliang Li,Haji Akber Aisa,Jun Li
标识
DOI:10.1002/cbdv.202300079
摘要
Six undescribed germacrane-type sesquiterpene lactones, millefoliumons A-F, and two known analogs were isolated from the ethyl acetate fraction of the whole plant of Achillea millefolium L. growing in Xinjiang, China. The structures of these compounds were fully elucidated by their 1D and 2D nuclear magnetic resonance (NMR), and high resolution mass (HR-ESI-MS) spectral data, and comparison with literatures. The absolute configurations of millefoliumons A-F were confirmed by experimental and calculated electronic circular dichroism data (ECD), and 13 C-NMR calculations and DP4+ probability analysis. All compounds displayed the approximate tendency to inhibit the nitric oxide (NO) release in lipopolysaccharide (LPS)-induced BV2 cells.
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