封堵器
势垒函数
结肠炎
溃疡性结肠炎
炎症性肠病
炎症
肿瘤坏死因子α
免疫学
医学
促炎细胞因子
右旋糖酐
内科学
紧密连接
化学
生物
疾病
生物化学
细胞生物学
作者
Yeon-Ji Kim,Han-Hae Kim,Cheung Soo Shin,Jong-Won Yoon,Seon-min Jeon,Young‐Ha Song,Kwang-Youn Kim,Kyung-Ho Kim
出处
期刊:Nutrients
[MDPI AG]
日期:2023-04-12
卷期号:15 (8): 1845-1845
被引量:1
摘要
Ulcerative colitis is an inflammatory bowel disease (IBD) with relapsing and remitting patterns, and it is caused by varied factors, such as the intestinal inflammation extent and duration. We examined the preventative effects of human milk oligosaccharides (HMOs) on epithelial barrier integrity and intestinal inflammation in an interleukin (IL)-6-induced cell model and dextran sodium sulfate (DSS)-induced acute mouse colitis model. HMOs including 2'-fucosyllactose (FL) and 3-FL and positive controls including fructooligosaccharide (FOS) and 5-acetylsalicylic acid (5-ASA) were orally administrated once per day to C57BL/6J mice with colitis induced by 5% DSS in the administered drinking water. 2'-FL and 3-FL did not affect the cell viability in Caco-2 cells. Meanwhile, these agents reversed IL-6-reduced intestinal barrier function in Caco-2 cells. Furthermore, 2'-FL and 3-FL reversed the body weight loss and the remarkably short colon lengths in DSS-induced acute colitis mice. Moreover, 2'-FL and 3-FL obviously protected the decreasing expression of zonula occluden-1 and occludin in colon tissue relative to the findings in the DSS-treated control group. 2'-FL and 3-FL significantly reduced IL-6 and tumor necrosis factor-α levels in serum relative to the control findings. The summary of these results shows that HMOs prevent colitis mainly by enhancing intestinal barrier function and advancing anti-inflammatory responses. Therefore, HMOs might suppress inflammatory responses and represent candidate treatments for IBD that protect intestinal integrity.
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