A sustainable vortex-assisted matrix solid phase dispersion for the simultaneous extraction of five active components from Saposhnikoviae Radix

Saposhnikoviae Radix (SR), one of top-grade herbs, is widely used to treat cold, headache, fevers, cough, rheumatism and cardiovascular diseases in prescriptions. A vortex-assisted matrix solid phase dispersion (VA-MSPD) extraction method applying a reusable dispersant was developed to extract four chromones and one coumarin from Saposhnikoviae Radix (SR), which followed by high performance liquid chromatography analysis (HPLC). The novel dispersant, acetonitrile modified carbon-coated magnetite nanoparticles (Fe3O4@[email protected] ACN MNP), could be reused for 10 times and it still possesses excellent extraction performance. Various optimal experimental condition of VA-MSPD was considered and obtained reliable matrix linearity (r2 > 0.999) and good recovery (94.8%–105%). In order to recovery the dispersant from sample-dispersant powder after elution, methanol/water (50:50, v/v) was applied as washing solution to separate the dispersant and samples, so that the percent recovery of modified materials was obtained as 88.6% (RSD = 0.74%). The results indicated that Fe3O4@[email protected] MNP could be considered as sustainable dispersant and it exhibited tremendous potential for efficacious extraction of chromones and coumarins.