Rhodium(III)‐Catalyzed Cascade C−H Coupling/C‐Terminus Michael Addition of N‐Phenoxy Amides with 1,6‐Enynes

Abstract Described herein is a Rh(III)‐catalyzed regio‐/stereoselective C−H coupling/C‐terminus Michael addition cascade of N ‐phenoxy amides with 1,6‐enynes, giving access to bicyclic frameworks with the retention of the oxidizing directing groups. Thus, it also provides a straightforward platform for subsequent derivatization via two‐fold C−H functionalization. Mechanistic studies elucidate the tandem reaction path and the coordination effect in tuning the observed manifold.