Episodic Nontoxic Erythema

We would like to confirm and extend the article by Manders et al.1We have seen 2 patients with a similar recurrent erythema that we believed to be due to an immune-mediated response to antigens that did not fit the classic descriptions of mucocutaneous lymph node disease, toxic shock syndrome, scarlet fever, staphylococcal scalded skin syndrome, or drug eruptions. Report of Cases.Case 1. A 27-year-old woman had a 10-year history of recurrent skin eruptions that she characterized as usually having been preceded by upper respiratory tract symptoms, malaise, or fever. The eruptions had no correlation to the onset of menstruation, and there were no arthralgia, myalgia, or joint symptoms. Swelling of her extremities was followed by a generalized sunburnlike erythema with tenderness. A mild erythema with superficial desquamation of the dorsal surfaces of her hands and legs was present. Approximately 1 week later, she had generalized desquamation accentuated