Objective: To explore the possible causes of ventilator-associated pneumonia and the corresponding nursing strategy. Methods: To review the clinical characteristics and bacterial spectra of 17 cases of ventilator-associated pneumonia(VAP) in the respiratory intensive care u-nit. Results: Among the 36-case mechanical ventilation patients, 17casessuffered from VAP, and 4 patients died, The morbidity and mortality was 47. 22% , and 23. 52% respectively. Conclusion: In addition to practicing the routine nursing, masting strictly the indication of mechanical ventilation, combining noninvasive and invasive mechanical ventilation in the early stage may reduce in incidence of VAP in the RICU.