精神分裂症(面向对象编程)
谷氨酸受体
致电离效应
NMDA受体
医学
神经科学
中枢神经系统
癫痫
萧条(经济学)
神经系统
受体
下调和上调
疾病
生物
精神科
内科学
经济
宏观经济学
基因
生物化学
作者
Kai Chen,Liu Nan Yang,Chuan Lai,Dan Liú,Ling‐Qiang Zhu
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2020-09-01
卷期号:18 (9): 861-867
被引量:13
标识
DOI:10.2174/1570159x18666200303104235
摘要
Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been reported in multiple diseases in human beings, such as major depressive disorder (MDD) and schizophrenia (SCZ), with which the underlying mechanisms remain elusive. In this review, we provide a general overview of the expression and physiological function of GRINA in the central nervous system (CNS) diseases, including stroke, depression ,epilepsy, SCZ, and Alzheimer’s disease (AD).
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