静脉切开术
医学
病因学
重症监护医学
血色病
去铁斯若
遗传性血色病
内科学
缺铁
静脉注射铁
儿科
生物信息学
生物
地中海贫血
作者
Tadeu Gonçalves de Lima,Fernanda Luna Neri Benevides,Flávio Moura Rezende Filho,Igor Braga Farias,Diovana Ximenes Cavalcante Dourado,Eveline Gadelha Pereira Fontenele,Maria Elisabete Amaral de Moraes,Ana Rosa Pinto Quidute
出处
期刊:Revista Da Associacao Medica Brasileira
[SciELO]
日期:2019-10-10
卷期号:65 (9): 1216-1222
被引量:6
标识
DOI:10.1590/1806-9282.65.9.1216
摘要
SUMMARY INTRODUCTION Iron overload is a broad syndrome with a large spectrum of causative etiologies that lead to iron deposition. When iron exceeds defenses, it causes oxidative damage and tissular disfunction. Treatment may prevent organ dysfunction, leading to greater life expectancy. METHODS Literature from the last five years was reviewed through the use of the PubMed database in search of treatment strategies. DISCUSSION Different pharmacological and non-pharmacological strategies are available for the treatment of iron overload and must be used according to etiology and patient compliance. Therapeutic phlebotomy is the basis for the treatment of hereditary hemochromatosis. Transfusional overload patients and those who cannot tolerate phlebotomy need iron chelators. CONCLUSION Advances in the understanding of iron overload have lead to great advances in therapies and new pharmacological targets. Research has lead to better compliance with the use of oral chelators and less toxic drugs.
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