Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Rheumatoid arthritis (RA) is a systemic disease characterized by autoimmunity, joint inflammation, and cartilage destruction, which affects 0.5–1% of the population. Many compounds from herbal medicines show the potentials to treat RA. On this basis, the compounds with good pharmacokinetic behaviors and drug‐likeness properties will be further studied and developed. Therefore, the herbal compounds with anti‐RA activities were reviewed in this paper, and the cheminformatics tools were used to predict their drug‐likeness properties and pharmacokinetic parameters. A total of 90 herbal compounds were analyzed, which were reported to be effective on RA models through anti‐inflammation, chondroprotection, immunoregulation, antiangiogenesis, and antioxidation. Most of the herbal compounds have good drug‐likeness properties. Most of the compounds can be an alternative and valuable source for anti‐RA drug discovery.