抗菌剂
细菌
伤口愈合
抗菌肽
肽
化学
自愈水凝胶
纳米点
活性氧
生物膜
抗菌活性
血红素
微生物学
生物物理学
生物化学
医学
生物
免疫学
酶
有机化学
物理化学
血红素
遗传学
作者
Xuan Wang,Lin Qiu,Cheng Wang,Zihan Gao,Shuwen Zhou,Pengfei Cui,Pengju Jiang,Huaanzi Hu,Xiaomin Ni,Xuancheng Du,Jianhao Wang,Jiang Xia
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:10 (3): 654-664
被引量:25
摘要
Bacterial infection of wounds delays the healing process, increases the risk of chronic trauma associated with pain and complications, and offers a breeding ground for drug-resistant bacteria. A rapid and effective eradication of the bacterial species in the wound area is thus important. Herein, we designed a phototherapeutic antibacterial platform based on peptides and copper sulfide nanodots (CuS NDs) for multi-mechanistic eradication of bacteria colonized on the wound surface. The antimicrobial peptide weaves into a network in the form of a hydrogel, which supports CuS NDs to generate heat and produce reactive oxygen species (ROS) under the irradiation of near-infrared light (NIR). The heat and ROS generated in situ act as non-contact-based antibacterial factors and together with contact-based antimicrobial peptides cause irreversible membrane destruction, cell content damage, and thermal ablation of the bacteria. Lastly, nanodot-doped peptide hydrogels combined with collagen showed complete bacterial elimination and significantly accelerated wound healing in a splint-fixed mouse infection model.
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