光学相干层析成像
弹性成像
弹性(物理)
计算机科学
刚度
流离失所(心理学)
软组织
光学
材料科学
生物医学工程
连贯性(哲学赌博策略)
医学
超声波
物理
声学
放射科
复合材料
心理治疗师
量子力学
心理学
作者
Mitchell A. Kirby,Ivan Pelivanov,Shaozhen Song,Łukasz Ambroziński,Soon Joon Yoon,Liang Gao,Tueng T. Shen,Matthew O’Donnell
标识
DOI:10.1117/1.jbo.22.12.121720
摘要
Optical coherence elastography (OCE) can provide clinically valuable information based on local measurements of tissue stiffness. Improved light sources and scanning methods in optical coherence tomography (OCT) have led to rapid growth in systems for high-resolution, quantitative elastography using imaged displacements and strains within soft tissue to infer local mechanical properties. We describe in some detail the physical processes underlying tissue mechanical response based on static and dynamic displacement methods. Namely, the assumptions commonly used to interpret displacement and strain measurements in terms of tissue elasticity for static OCE and propagating wave modes in dynamic OCE are discussed with the ultimate focus on OCT system design for ophthalmic applications. Practical OCT motion-tracking methods used to map tissue elasticity are also presented to fully describe technical developments in OCE, particularly noting those focused on the anterior segment of the eye. Clinical issues and future directions are discussed in the hope that OCE techniques will rapidly move forward to translational studies and clinical applications.
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