Hydrogel sunscreen based on yeast /gelatin demonstrates excellent UV-shielding and skin protection performance

• The hydrogel sunscreen firstly uses yeast as effective component. • The hydrogel sunscreen shows satisfactory UV protection capability in vitro and in vivo. • The hydrogel sunscreen shows high stability. • The hydrogel sunscreen is prepared conveniently. Traditional organic and inorganic sunscreens suffer from the disadvantages of low stability and poor biocompatibility. In the study, we developed a novel hydrogel sunscreen based on the yeast and gelatin, which demonstrated excellent UV protection property and broad absorption of UV across UVA and UVB region. Yeast was used as effective component and gelatin as matrix to fabricate the hydrogel, which is high hydrated and reasonable to simulate natural living tissue. As a common probiotic, yeast shows safety and satisfactory UV protection capability. Furthermore, the hydrogel sunscreen shows excellent biocompatibility and UV protection performance both in vitro and in vivo . Moreover, they can be prepared conveniently and provide an eco-friendly strategy, which provides experience and inspiration of probiotics in the cosmetics application.