细胞内
纳米载体
细胞外
背景(考古学)
细胞外小泡
脂质体
药物输送
化学
微泡
细胞生物学
生物物理学
纳米技术
生物
生物化学
材料科学
基因
小RNA
古生物学
作者
Sarah Le Saux,Anne Aubert-Pouëssel,Khaled Elhady Mohamed,Pierre Martineau,Laurence Guglielmi,Jean-Marie Devoisselle,Philippe Legrand,Joël Chopineau,Marie Morille
标识
DOI:10.1016/j.addr.2021.113837
摘要
Compared to chemicals that continue to dominate the overall pharmaceutical market, protein therapeutics offer the advantages of higher specificity, greater activity, and reduced toxicity. While nearly all existing therapeutic proteins were developed against soluble or extracellular targets, the ability for proteins to enter cells and target intracellular compartments can significantly broaden their utility for a myriad of exiting targets. Given their physical, chemical, biological instability that could induce adverse effects, and their limited ability to cross cell membranes, delivery systems are required to fully reveal their biological potential. In this context, as natural protein nanocarriers, extracellular vesicles (EVs) hold great promise. Nevertheless, if not present naturally, bringing an interest protein into EV is not an easy task. In this review, we will explore methods used to load extrinsic protein into EVs and compare these natural vectors to their close synthetic counterparts, liposomes/lipid nanoparticles, to induce intracellular protein delivery.
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