心脏毒性
医学
伊马替尼
甲磺酸伊马替尼
药理学
肌肉肥大
心力衰竭
心肌细胞
内科学
氨氯地平
细胞凋亡
化疗
化学
血压
生物化学
髓系白血病
作者
Armin Wolf,Philippe Couttet,Min Dong,Olivier Grenet,Marcia I. Heron,Ursula Junker,Ulrich Wilhelm Laengle,Lior David,Estelle Marrer,Anja Nussher,Elke Persohn,François Philippe,Gilles-Jacques Rivière,Daniel Roth,Christian Trendelenburg,Jeffrey Tsao,Danielle Roman
标识
DOI:10.1016/j.leukres.2010.01.004
摘要
Cytotoxic concentrations of imatinib mesylate (10-50 microM) were required to trigger markers of apoptosis and endoplasmic reticulum stress response in neonatal rat ventricular myocytes and fibroblasts, with no significant differences observed between c-Abl silenced and nonsilenced cells. In mice, oral or intraperitoneal imatinib treatment did not induce cardiovascular pathology or heart failure. In rats, high doses of oral imatinib did result in some cardiac hypertrophy. Multi-organ toxicities may have increased the cardiac workload and contributed to the cardiac hypertrophy observed in rats only. These data suggest that imatinib is not cardiotoxic at clinically relevant concentrations (5 microM).
科研通智能强力驱动
Strongly Powered by AbleSci AI