Fibre optic ATR-IR spectroscopy at cryogenic temperatures: in-line reaction monitoring on organolithium compounds

A reliable methodology, utilising an ATR-IR fibre probe, for in-line monitoring of low temperature reactions is presented. The application of this convenient set-up enables a fast and safe exploration of highly reactive substrates. Hence, in situ monitoring of lithiation reactions is realised and the potential to investigate sensitive intermediates is being demonstrated.