药品
血浆蛋白结合
药物作用
血液蛋白质类
体内
化学
数量结构-活动关系
结合位点
药代动力学
药理学
行动地点
血浆浓度
生物化学
生物
立体化学
医学
内科学
生物技术
作者
Snežana Agatonović-Kuštrin,David W. Morton,Pauzi A. Yusof
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2014-05-29
卷期号:14 (6): 484-493
被引量:1
标识
DOI:10.2174/1389557514666140529223057
摘要
Most drugs are carried from the site of absorption to their intended site of action (target site) by the bloodstream, either dissolved in the serum or bound to plasma proteins. Binding to plasma proteins influences (i.e. limits or favours), drug distribution through the body. Usually it is the unbound drug concentration that determines its pharmacological and toxicological properties. Our ability to design suitable drug candidates depends on our ability to understand the molecular characteristics of drug-protein binding and ideally be able to predict the extent of binding in vivo. Here we review the different approaches that have been used to model and predict the binding of drugs and drug like molecules to plasma proteins in the body.
科研通智能强力驱动
Strongly Powered by AbleSci AI