Diagnosis and treament of mood disorder in the patients with chronic gastritis and helicobacter pylori

Objective To investigate the diagnosis of mood disorder in patients with chronic gastritis infected with helicobacter pylori (Hp), and explore the effects of different therapies. Methods The psychological status of chronic gastritis infected with Hp (two hundred and eighty cases) was analyzed with Hamilton Depression/Anxiety (HAMD /HAMA) Scales.Additionally, the patients with depression or anxiety (ninty-three cases) were randomly divided into three groups: group A received routine and antidepressant treatments, group B received antidepressant treatment and group C received routine treatment.Efficacy was assessed by patients’ perception of overall digestive symptoms and HAMD/HAMA Scales, and the infection of Hp was detected by 13C-urea Breath test (13C-UBT). Results The prevalence rate of depression or anxiety in chronic gastritis with Hp by the worry about cancer was 33.2% (93/280). The positive rate of 13C-UBT was 12.0% (9/30)in group A, 89.0% (25/28)in group B, 16.7% (5/30) in group C after 8-week treatment.The severity of patients’ perception of overall digestive symptoms was significantly improved in group A after 8-week treatment(25.3±4.1, 11.4±1.6, t=14.1, P 0.05). There was significant difference of overall digestive symptoms in group A or B compared with that in group C (t=7.3, 5.2; P 0.05). The total clinical efficiency of mood disorder were 85.0%, 81.0% and 38.0%. Conclusions The prevalence rate of depression and anxiety is higher in chronic gastritis infected with Hp.Routine treatment is ineffective, and antidepressant treatment is partly effective.The combination of both treatments can effectively improve their somatic and psychiatric symptoms. Key words: Chronic gastritis; Helicobacter pylori; Mood disorder; Antidepressant treatment