STAT6
癌症研究
癌变
生物
信号转导
磷酸化
肿瘤进展
转移
转录因子
细胞生物学
癌症
遗传学
基因
作者
Hao Huang,Yizhou Zheng,Linfu Li,Weimei Shi,Rui Zhang,Hai Liu,Zhixi Chen,Longhuo Wu
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2020-11-01
卷期号:12 (21): 1945-1960
被引量:7
标识
DOI:10.4155/fmc-2020-0224
摘要
Signal transducers and activators of transcription 6 (STAT6) are highly expressed in various tumors and associated with tumorigenesis, immunosuppression, proliferation, metastasis and poor prognosis in human cancers. In response to IL-4/13, STAT6 is phosphorylated, dimerizes and triggers transcriptional regulation after recruitment of coactivators to transcriptosome, such as CBP/p300, SRC-1, PARP-14 and PSF. Post-translational modifications, including phosphorylation, ubiquitination, ADP-ribosylation and acetylation, have been explored for molecular mechanisms of STAT6 in tumor development and management. STAT6 has been developed as a specific biomarker for distinguishing and diagnosing tumor phenotypes, although it is observed to be frequently mutated in metastatic tumors. In this article, we focus mainly on the structural characteristics of STAT6 and its role in tumor growth and progression.
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