光热治疗
药物输送
免疫系统
体内
细胞毒性T细胞
阿霉素
胞外囊泡
紫杉醇
癌细胞
癌症
化学
癌症研究
纳米技术
医学
药理学
体外
化疗
生物
免疫学
微泡
材料科学
内科学
生物化学
小RNA
基因
生物技术
有机化学
作者
Yanghui Bi,Jieya Chen,Qing Li,Yan Li,Ling Zhang,Zhida Liu,Fajia Yuan,Ruiping Zhang
出处
期刊:iScience
[Elsevier]
日期:2024-02-01
卷期号:27 (2): 108833-108833
被引量:2
标识
DOI:10.1016/j.isci.2024.108833
摘要
Tumor extracellular vesicles (EVs) demonstrate considerable promise for medication delivery and tumor targeting owing to their natural long-term blood circulation and tissue targeting capabilities. We extracted EVs from mouse breast cancer cell 4T1 using UV stimulation and differential centrifugation. To create a new nano-drug delivery system, the vesicle delivery system (EPM) loaded with melanin and paclitaxel albumin (PA), the collected EVs were repeatedly compressed on a 200 nm porous polycarbonate membrane with melanin and PA. Our findings suggest that EPM is readily absorbed by breast cancer and dendritic cells. EPM generates significant photoacoustic signals and photothermal effects when exposed to near-infrared light and can enhance the infiltration of CD8+ T cells in mouse tumor tissues. EPM is more cytotoxic than PA in in vivo and in vitro investigations. The efficacy of EPM in clinical transformation when paired with chemotherapy/photothermal/immunotherapy treatment is demonstrated in this study.
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