Macrophage Hitchhiking Nanoparticles for the Treatment of Myocardial Infarction: An In Vitro and In Vivo Study (Adv. Funct. Mater. 34/2023)

Heart Targeting Nanoparticles In article number 2303658, Hélder A. Santos, Antti Saraste, Vimalkumar Balasubramanian, Giulia Torrieri, and co-workers develop a dual drug-loaded acetalated dextran-based precision nanosystem, that relies on the heart targeting properties of atrial natriuretic peptide (ANP) and lin-TT1 peptide-mediated hitchhiking on M2-like macrophages to target the infarcted heart. These nanoparticles show increased heart targeting at day 7 post-MI compared to particles conjugated only with ANP.