偏头痛
医学
全国健康与营养检查调查
维生素D与神经学
内科学
置信区间
维生素
逻辑回归
体质指数
横断面研究
内分泌学
人口
环境卫生
病理
作者
Sheng Tian,Xinping Yu,Long‐Fei Wu,Heqing Zheng,X. Zhong,Yonggang Xie,Wei Wu
标识
DOI:10.1016/j.nutres.2023.11.008
摘要
Previous studies have shown that B vitamins can relieve migraine. However, the association between vitamin B6 and folate, 2 important B vitamins consumed in the diet, with migraine have received minimal attention. This study explored the independent relationships between dietary vitamin B6 and folate intake with migraine and the interaction effect of these 2 nutrients on migraine in US adults. We hypothesized that vitamin B6 and folate intake would be inversely associated with migraine. This study included cross-sectional data from participants aged 20 years and older who participated in the National Health and Nutrition Examination Survey from 1999 to 2004. We conducted multivariate logistic regression and restricted cubic spline regression to explore the association between dietary vitamin B6 and folate intake on migraine. Also, relative excess risk due to interaction, attributable proportion of interaction, and synergy index were used to assess additive interactions. A total of 7017 participants were included in this study, 1350 of whom were migraineurs. We determined that vitamin B6 and folate intake revealed a negative association with severe headache or migraine (0.66; 95% confidence interval [CI], 0.47–0.89; P = .01 and 0.57; 95% CI, 0.42–0.78; P = .002]), respectively. Also, a significant interaction effect between a high mass of vitamin B6 and folate intake was observed for a lower risk of migraine (relative excess risk due to interaction, 0.28 [95% CI, 0.05–0.51]; attributable proportion of interaction: 0.45 [95% CI, 0.05–0.86]; synergy index: 0.58 [95% CI, 0.40–0.83]). A high mass of vitamin B6 and folate intake (vitamin B6 intake ≥ 2.39 mg/day and folate intake ≥ 502.01 µg/day) presented a synergistic interaction with migraine, suggesting that these 2 nutrients might be beneficial in preventing migraine.
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