荧光显微镜
显微镜
荧光寿命成像显微镜
荧光
光学成像
计算机科学
分子成像
模态(人机交互)
模式
纳米技术
生物系统
生物医学工程
人工智能
材料科学
生物
医学
病理
光学
物理
体内
社会学
生物技术
社会科学
作者
Marcus E. Graziotto,Clinton J. Kidman,Liam D. Adair,Simon James,Hugh H. Harris,Elizabeth J. New
摘要
Imaging techniques permit the study of the molecular interactions that underlie health and disease. Each imaging technique collects unique chemical information about the cellular environment. Multimodal imaging, using a single probe that can be detected by multiple imaging modalities, can maximise the information extracted from a single cellular sample by combining the results of different imaging techniques. Of particular interest in biological imaging is the combination of the specificity and sensitivity of optical fluorescence microscopy (OFM) with the quantitative and element-specific nature of X-ray fluorescence microscopy (XFM). Together, these techniques give a greater understanding of how native elements or therapeutics affect the cellular environment. This review focuses on recent studies where both techniques were used in conjunction to study cellular systems, demonstrating the breadth of biological models to which this combination of techniques can be applied and the potential for these techniques to unlock untapped knowledge of disease states.
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