生物
非酒精性脂肪肝
肝硬化
纤维化
脂肪肝
内科学
肝细胞
基因型
肝病
炎症
内分泌学
库普弗电池
疾病
免疫学
基因
医学
遗传学
体外
作者
Huan Su,Madhuri Haque,Svea Becker,Karolina Edlund,Julia Duda,Qingbi Wang,Johanna Reißing,Hanns–Ulrich Marschall,Lena Susanna Candels,Mohamed Ramadan Mohamed,Wilhelm Sjöland,Lijun Liao,Stephan A. Drexler,Till Strowig,Jörg Rahnenführer,Jan G. Hengstler,Maximilian Hatting,Christian Trautwein
摘要
With long-term HFD feeding, mice with the PNPLA3 I148M genotype show exacerbated NAFLD. This finding is linked to PNPLA3 I148M-specific changes in microbiota composition and liver gene expression showing a stronger inflammatory response leading to enhanced liver fibrosis progression.
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