泰特
支原体
抑制因子
生物
转录调控
基因
调节器
遗传学
基因表达调控
细胞生物学
基因表达
分子生物学
结核分枝杆菌
医学
肺结核
病理
作者
Saloni Rajesh Wani,Abhishek Anil Dubey,Vikas Jain
出处
期刊:FEBS Letters
[Wiley]
日期:2023-01-30
卷期号:597 (10): 1428-1440
标识
DOI:10.1002/1873-3468.14582
摘要
Transcriptional factors such as the TetR family of transcriptional regulators (TFTRs) are widely found amongst bacteria, including mycobacteria, and are accountable for their survival. Here, we characterized a novel TFTR, Ms6244, from Mycobacterium smegmatis that negatively autoregulates its expression and represses its neighbouring gene, Ms6243 . We also report the binding of Ms6244 to the inverted repeats in the intergenic region of Ms6244 and Ms6243 . Further, an Ms6244 ‐deleted strain shows various morpho‐physiological differences compared to the wild type. We further confirmed that the deletion of Ms6244 itself and not the resultant Ms6243 overexpression is the cause of the altered physiology. Our data thus suggest that Ms6244 is an essential regulator, having far‐reaching effects on M. smegmatis physiology.
科研通智能强力驱动
Strongly Powered by AbleSci AI