A Self‐Priming Pyroptosis‐Inducing Agent for Activating Anticancer Immunity

⁺-catalyzed reactive oxygen species generation, which triggers NF-κB translocation and prime caspase-11 expression. Subsequently, lipopolysaccharides from OMVs activate caspase-11, resulting in GSDMD cleavage and pyroptosis induction. MnNZ@OMV significantly induces tumor pyroptosis in vivo, promoting dendritic cell maturation and CD8⁺ T cell activation, leading to robust anti-tumor effects. Collectively, this study presents a novel self-priming approach for inducing tumor cell pyroptosis through the noncanonical caspase-11/GSDMD pathway, offering a promising avenue for future cancer immunotherapy.