生物分析
药代动力学
化学
对映体
对映选择合成
超临界流体色谱法
手性(物理)
生物流体
组合化学
色谱法
药理学
高效液相色谱法
立体化学
有机化学
催化作用
手征对称破缺
物理
量子力学
夸克
医学
Nambu–Jona Lasinio模型
作者
V. V. S. Prasanna Kumari Rayala,Jony Susanna Kandula,P. Radhakrishnanand
出处
期刊:Chirality
[Wiley]
日期:2022-07-26
卷期号:34 (10): 1298-1310
被引量:20
摘要
Enantioselective analytical approaches are essential for monitoring pharmacokinetics and acquiring accurate data to better understand the role of stereochemistry in pharmacokinetics. Enantioselectivity significantly impacts the pharmacokinetics of chiral drugs, especially in metabolic profile, leading to toxicity of enantiomer. Consequently, there is a need to study the pharmacokinetics of enantiomerically pure drugs and racemates as they differ in affinity with enzymes and proteins. Combining the best enantioseparation conditions with the specified biological matrix and the intended purpose of the analysis is a challenging task. This review discusses the importance of chirality in stereoselective pharmacokinetics with more relevant examples, various enantioselective analytical techniques, and stationary phases employed. Challenges such as lack of universal chiral columns, biological inversion of the isomers, and others have been discussed. Further presented the recent advances in the screening of chiral drugs and innovative improvements in the analytical approaches for chiral molecule analysis such as supercritical fluid chromatography, simulated moving bed chromatography, and other techniques are discussed.
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