医学
免疫组织化学
H&E染色
病理
腺癌
细胞外基质
肺癌
肺
病态的
组织微阵列
基质金属蛋白酶
肿瘤科
肿瘤进展
癌症
内科学
生物
细胞生物学
作者
Kaede Yamada,Kyuichi Kadota,Syusuke Fujimoto,Chihiro Yoshida,Emi Ibuki,Ryou Ishikawa,Reiji Haba,Hiroyasu Yokomise,Toshiki Yajima
出处
期刊:Lung Cancer
[Elsevier]
日期:2023-01-01
卷期号:175: 125-130
被引量:1
标识
DOI:10.1016/j.lungcan.2022.12.001
摘要
The spread through air spaces (STAS) of adenocarcinoma (ADC) is a unique pattern for local invasion, which comprises the spread of tumor cells within air spaces beyond the tumor edge without a direct connection with the primary tumor. Matrix metalloproteinase-7 (MMP-7), a secreted proteolytic enzyme that degrades various extracellular matrix components and other substrates, regulates several pathophysiological processes as well as the occurrence and development of cancers in humans. Here, we retrospectively analyzed a cohort of Japanese patients with treatment-naive, surgically-resected lung ADC to assess whether MMP-7 is associated with STAS development and if it could be used as a predictor of STAS.We performed histological evaluation using hematoxylin and eosin staining and immunohistochemical analysis using microarrays. Thereafter, we scored the examined tissues for immune markers to identify significant tumor STAS predictors.We identified that high MMP-7 expression is an independent predictor of a high STAS incidence. Multivariate analysis revealed that MMP-7 expression was correlated with tumor behavior and poor prognosis. Furthermore, STAS remained significantly associated with a higher risk of ADC recurrence.The development of tumor STAS could be promoted by the functioning of MMP-7. This study could be a crucial basis for future investigations on the detection of tumor STAS.
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