Scale-Up Investigation of Aggarwal Enal Bicyclic Intermediate Synthesis

Recently, a multitude of modern and short syntheses of various prostanoids were reported, rejuvenating this synthesis field. One such synthesis reported by Aggarwal et al. has good potential for industrialization. Herein, synthesis of bicyclic enal intermediate (Aggarwal enal) was demonstrated on a hectogram scale by finding an appropriate l-proline source which is soluble under overhead stirring conditions in reactor. Kilogram scale synthesis of volatile starting material─succinaldehyde─was achieved in a high yield by finding a suitable isolation method.