固体脂质纳米粒
气溶胶化
色谱法
甘露醇
等温滴定量热法
化学
海藻糖
超声
药物输送
差示扫描量热法
喷雾干燥
纳米颗粒
泊洛沙姆
作者
Diana P. Gaspar,Maria Manuela Gaspar,Carla Eleutério,Ana Grenha,Mateo Blanco,Lídia Gonçalves,Pablo Taboada,António J. Almeida,Carmen Remuñán-López
标识
DOI:10.1021/acs.molpharmaceut.7b00169
摘要
Solid lipid nanoparticles (SLN) containing rifabutin (RFB), with pulmonary administration purposes, were developed through a technique that avoids the use of organic solvents or sonication. To facilitate their pulmonary delivery, the RFB-loaded SLN were included in microspheres of appropriate size using suitable excipients (mannitol and trehalose) through a spray-drying technique. Confocal analysis microscopy showed that microspheres are spherical and that SLN are efficiently microencapsulated and homogeneously distributed throughout the microsphere matrices. The aerodynamic diameters observed an optimal distribution for reaching the alveolar region. The dry powder’s performance during aerosolization and the in vitro drug deposition were tested using a twin-impinger approach, which confirmed that the microspheres can reach the deep lung. Isothermal titration calorimetry revealed that SLN have higher affinity for mannitol than for trehalose. Upon microsphere dissolution in aqueous media, SLN were readily r...
科研通智能强力驱动
Strongly Powered by AbleSci AI