亚精胺
多胺
自噬
锡尔图因
神经保护
癌症
热卡限制
衰老
医学
疾病
药理学
生物
细胞生物学
乙酰化
生物化学
内分泌学
内科学
遗传学
细胞凋亡
酶
基因
作者
Frank Madeo,Tobias Eisenberg,Federico Pietrocola,Guido Kroemer
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2018-01-26
卷期号:359 (6374)
被引量:657
标识
DOI:10.1126/science.aan2788
摘要
Interventions that delay aging and protect from age-associated disease are slowly approaching clinical implementation. Such interventions include caloric restriction mimetics, which are defined as agents that mimic the beneficial effects of dietary restriction while limiting its detrimental effects. One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates anticancer immunosurveillance in rodent models. Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related mortality in human epidemiological studies. Spermidine preserves mitochondrial function, exhibits anti-inflammatory properties, and prevents stem cell senescence. Mechanistically, it shares the molecular pathways engaged by other caloric restriction mimetics: It induces protein deacetylation and depends on functional autophagy. Because spermidine is already present in daily human nutrition, clinical trials aiming at increasing the uptake of this polyamine appear feasible.
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