Expression of bcl-2 in Gastrointestinal Stromal Tumors

Objective To investigate the expression of bcl-2 in gastrointestinal stromal tumors (GIST). Methods The expression of bcl-2, CD 117 and CD 34 were detected in 51 cases of GIST with Envision immunohistochemical method. Results In 51 GIST, the positive rates of CD 117 and CD 34 were 100 % and 76. 5 % . The expression of bcl-2 were observed in 45 of 51 cases (88.2 % ), and the positive rates of the benign, borderline and the malignant GIST were 100%, 91. 7% and 82. 8% respectively. There was no significant difference in expression of bcl-2 between the benign GIST and malignant GIST. Conclusion Bcl-2 may serve as a supplemental marker of GIST for diagnosis, which may not be used as the index to distinguish the benign GIST from the malignant GIST.