Establishment of tumor multidrug resistance model and its evaluation methods

This study intends to review the methods of building tumor multidrug resistance(MDR) models and animal model.The establishment methods,characteristics,evaluation tools,and the study significance of the models including MDR cells and MDR animals were analyzed and summarized.It could provide a reference to establish an advanced MDR model,and to optimize the evaluation model of antitumor drugs.It could also be helpful to clarify the mechanisms of MDR and may provide the guidance for the clinical usage of antitumor drugs.