诱导多能干细胞
重组激活基因
细胞生物学
免疫系统
细胞分化
生物
体外
免疫学
遗传学
胚胎干细胞
基因
重组
作者
Patrick M. Brauer,Itai M. Pessach,Erik Clarke,Jared H. Rowe,Lisa Ott de Bruin,Yu Nee Lee,Carmen Dominguez‐Brauer,Anne Marie Comeau,Génève Awong,Kerstin Felgentreff,Yuhang H. Zhang,Andrea Bredemeyer,Waleed Al–Herz,Likun Du,Francesca A. Ververs,Marion Kennedy,Silvia Giliani,Gordon Keller,Barry P. Sleckman,David G. Schatz
出处
期刊：Blood
[Elsevier BV]
日期：2016-06-15
卷期号：128 (6): 783-793
被引量：46
标识
DOI：10.1182/blood-2015-10-676304
摘要
Key Points Upon in vitro differentiation, iPSCs obtained from patients with SCID and OS show a similar block in T-cell development. Presence of unresolved single-strand DNA breaks in developing T cells from OS patient-derived iPSCs affects their differentiation.
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