Objective: To observe the efficacy of hyperbaric oxygen in the treatment of traumatic brain injury.Methods: 100 cases of patients with traumatic brain injury were divided into control group and experiment group,conventional treat-ment was used in two groups,and hyperbaric oxygen was added in the experiment group.The efficacy in the two groups and the effects on GCS score were observed.Results: Compared with the control group,the total effective rate increased significantly(P0.05) and GCS score increased(P0.05) after treatment in the experiment group.Conclusion: Hyperbaric oxygen therapy can improve the GCS score,curative efficacy and the quality of life for patients with traumatic brain injury.