化学
结合
锂(药物)
立体化学
对映选择合成
氨基酸
组合化学
有机化学
催化作用
生物化学
数学
医学
内分泌学
数学分析
作者
Steven D. Bull,Stephen G. Davies,Paul M. Roberts,Edward D. Savory,Andrew D. Smith
出处
期刊:Tetrahedron
[Elsevier]
日期:2002-06-01
卷期号:58 (23): 4629-4642
被引量:23
标识
DOI:10.1016/s0040-4020(02)00369-1
摘要
A strategy for the asymmetric synthesis of homochiral [(R,R)- or (S,S)-], or meso-(R,S) bis-β-amino acid scaffolds, formally resulting from the stepwise conjugate addition of two differentially protected homochiral lithium amides to two α,β-unsaturated esters attached to a central arene, is demonstrated. Further manipulation enables the efficient synthesis of orthogonally protected pseudo-meso or pseudo-C2 symmetric scaffolds via selective N-benzyl or N-allyl deprotection, enabling regio-, stereo- and chemoselective functionalisation.
科研通智能强力驱动
Strongly Powered by AbleSci AI