医学
坏死性下垂
心肌梗塞
心脏病学
缺血
坏死
再灌注损伤
内科学
病理生理学
死因
程序性细胞死亡
疾病
细胞凋亡
生物化学
化学
标识
DOI:10.1016/j.ijcard.2021.04.042
摘要
Myocardial ischemia-reperfusion injury is an important factor that seriously affects the prognosis of patients with myocardial infarction. It can cause myocardial stun, no-reflow phenomenon, reperfusion arrhythmia, and even irreversible cardiomyocyte death. Regulated necrosis is a newly discovered type of regulatory cell death that is different from apoptosis, including necroptosis, pyrolysis, iron death and other forms. Regulated necrosis plays an important role in myocardial infarction, heart failure and other cardiovascular diseases, as well as myocardial ischemia-reperfusion injury and other pathophysiological processes, and is expected to become a new target for intervention in this type of disease.
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