癌症研究
血管生成
医学
小RNA
自噬
信号转导
癌症
缺氧(环境)
生物标志物
转移
上皮-间质转换
生物
基因
内科学
细胞生物学
细胞凋亡
有机化学
化学
氧气
生物化学
作者
Yu-Yuan Chen,Sheng Huang,Rong Guo,Dedian Chen
出处
期刊:Biomarkers in Medicine
[Future Medicine]
日期:2021-12-01
卷期号:15 (18): 1769-1783
被引量:4
标识
DOI:10.2217/bmm-2021-0298
摘要
Metadherin (MTDH) has been recognized as a novel protein that is critical for the progression of multiple types of human malignancies. Studies have reported that MTDH enhances the metastatic potential of cancer cells by regulating multiple signaling pathways. miRNAs and various tumor-related proteins have been shown to interact with MTDH, making it a potential therapeutic target as well as a biomarker in human malignancies. MTDH plays a critical role in inflammation, angiogenesis, hypoxia, epithelial-mesenchymal transition and autophagy. In this review, we present the function and mechanisms of MTDH for cancer initiation and progression.
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