毒性
纳米材料
纳米技术
氧化还原
材料科学
医学
内科学
冶金
作者
Aniruddha Adhikari,Susmita Mondal,Mousumi Das,Ria Ghosh,Pritam Biswas,Soumendra Darbar,Soumendra Singh,Anjan Kumar Das,Siddhartha Bhattacharya,Debasish Pal,Asim Kumar Mallick,Samir Kumar Pal
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2021-06-01
卷期号:7 (6): 2475-2484
被引量:12
标识
DOI:10.1021/acsbiomaterials.1c00402
摘要
Precise control of intracellular redox status, i.e., maintenance of the physiological level of reactive oxygen species (ROS) for mediating normal cellular functions (oxidative eustress) while evading the excess ROS stress (distress), is central to the concept of redox medicine. In this regard, engineered nanoparticles with unique ROS generation, transition, and depletion functions have the potential to be the choice of redox therapeutics. However, it is always challenging to estimate whether ROS-induced intracellular events are beneficial or deleterious to the cell. Here, we propose the concept of redox buffering capacity as a therapeutic index of engineered nanomaterials. As a steady redox state is maintained for normal functioning cells, we hypothesize that the ability of a nanomaterial to preserve this homeostatic condition will dictate its therapeutic efficacy. Additionally, the redox buffering capacity is expected to provide information about the nanoparticle toxicity. Here, using citrate-functionalized trimanganese tetroxide nanoparticles (C-Mn3O4 NPs) as a model nanosystem, we explored its redox buffering capacity in erythrocytes. Furthermore, we went on to study the chronic toxic effect (if any) of this nanomaterial in the animal model to co-relate with the experimentally estimated redox buffering capacity. This study could function as a framework for assessing the capability of a nanomaterial as redox medicine (whether maintains eustress or damages by creating distress), thus orienting its application and safety for clinical use.
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