A review: Structure-activity relationship and antibacterial activities of Quinoline based hybrids

• In this review we have discussed the antibacterial activity of quinoline-based hybrids and their SAR study. • The SAR provides a better perspective for synthesizing bioactive quinoline analogs. • SAR study was also persuaded for each type of hybrid which revealed that type of moiety and EWG or EDG substitution on different moieties play a vital role in bacterial activity. • This review signifies the leading role of quinoline hybrids for future improvement of antibiotics. The drug resistance problem is most acute in the case of bacteria. There is always a need to develop novel antibacterial drugs with better mechanisms of action. Most of the quinoline-based antibiotics developed are potential antibacterial drug candidates. This review represents quinoline-based hybrids with antibacterial activity and their structure–activity relationship (SAR), which provide further insight into the improvement of quinoline-based antibiotics especially against multidrug-resistant bacterial strains.