狭缝
胰腺癌
生物
轴突引导
间质细胞
癌症
细胞生物学
轴突
信号转导
癌症研究
神经科学
遗传学
作者
Paola Martinelli,Francisco X. Real
标识
DOI:10.1016/j.trecan.2019.02.004
摘要
The SLIT/ROBO pathway is classically known for its role in axon guidance, and is frequently lost in pancreatic cancer, but the biology behind this is poorly understood. Two recent articles (Nat. Commun. 2018;9:5082; Nat. Commun. 2018;9:5083) using mouse models show that SLIT/ROBO signaling is crucial to determine pancreatic cell identity during development and suppresses the stromal activation in disease, through divergent mechanisms. SLIT/ROBO proteins thus link development and cancer, but appear to have distinct functions in health and disease.
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