Construction of dense film inside capillary wall and SERS application research

The high-density particle distribution in capillary was a crucial factor for enhancing SERS properties and a difficult point in the preparation process. The direct high-temperature method was used to fuse the particles and form a uniform and dense particle distribution on the capillary's inner wall, providing a foundation for enhancing Raman signals. The prepared capillary SERS substrate strongly enhances the rhodamine 6G (R6G) signal, and the RSD values of several characteristic peaks of R6G are about 10 %, demonstrating high sensitivity, uniformity, and stability. Using capillary SERS substrate for detecting goat serum. Embedding precious metal particles into capillary SERS substrate can effectively encapsulate the tested liquid and avoid contamination, which improves the disadvantage of traditional substrates exposing the liquid to air. The prepared capillary SERS substrate could be used for field and biomedical sensitivity detection, providing a theoretical and experimental basis for developing the capillary SERS substrate.