免疫疗法
医学
癌症
癌症免疫疗法
药品
药物输送
药理学
全身给药
自愈水凝胶
癌症治疗
生物材料
免疫系统
免疫学
生物医学工程
内科学
纳米技术
体内
材料科学
生物
生物技术
高分子化学
作者
Khizra Mujahid,Isra Rana,Ibnauf Suliman,Zhen Li,Jiang Wu,Huacheng He,Jutaek Nam
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2023-12-05
标识
DOI:10.1021/acsabm.3c00808
摘要
Cancer immunotherapy has revolutionized clinical cancer treatments by taking advantage of the immune system to selectively and effectively target and kill cancer cells. However, clinical cancer immunotherapy treatments often have limited efficacy and/or present severe adverse effects associated primarily with their systemic administration. Localized immunotherapy has emerged to overcome these limitations by directly targeting accessible tumors via local administration, reducing potential systemic drug distribution that hampers drug efficacy and safety. Sustained-release formulations can prolong drug activity at target sites, which maximizes the benefits of localized immunotherapy to increase the therapeutic window using smaller dosages than those used for systemic injection, avoiding complications of frequent dosing. The performance of sustained-release formulations for localized cancer immunotherapy has been validated preclinically using various implantable and injectable scaffold platforms. This review introduces the sustained-release formulations developed for localized cancer immunotherapy and highlights their biomaterial-based platforms for representative classes, including inorganic scaffolds, natural hydrogels, synthetic hydrogels, and microneedle patches. The design rationale and other considerations are summarized for further development of biomaterials for the construction of optimal sustained-release formulations.
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