自愈水凝胶
生物相容性
壳聚糖
伤口愈合
乙二醇
材料科学
生物高聚物
生物医学工程
生物材料
水溶液
化学
化学工程
纳米技术
高分子化学
聚合物
复合材料
外科
有机化学
医学
冶金
工程类
作者
Karol Kłosiński,Radosław A. Wach,Małgorzata K Girek-Bąk,Bożena Rokita,Damian Kołat,Żaneta Kałuzińska,Barbara Kłosińska,Łukasz Duda,Zbigniew Pasieka
出处
期刊:Polymers
[MDPI AG]
日期:2022-12-28
卷期号:15 (1): 144-144
被引量:7
标识
DOI:10.3390/polym15010144
摘要
Hydrogels have the properties of solid substances and are useful for medicine, e.g., in systems for the controlled release of drugs or as wound dressings. They isolate the wound from the external environment and constitute a barrier to microorganisms while still being permeable to oxygen. In the current study, hydrogels were formed from concentrated aqueous solutions of carboxymethyl chitosan (CMCS) via electron beam irradiation, with the presence of a crosslinking agent: poly(ethylene glycol)diacrylate. The aim of the study was to compare the properties and action of biopolymer CMCS hydrogels with commercial ones and to select the best compositions for future research towards wound-dressing applications. The elasticity of the gel depended on the component concentrations and the irradiation dose employed to form the hydrogel. Young’s modulus for the tested hydrogels was higher than for the control material. The Live/Dead test performed on human fibroblasts confirmed that the analyzed hydrogels are not cytotoxic, and for some concentrations, they cause a slight increase in the number of cells compared to the control. The biocompatibility studies carried out on laboratory rats showed no adverse effect of hydrogels on animal tissues, confirming their biocompatibility and suggesting that CMCS hydrogels could be considered as wound-healing dressings in the future. Ionizing radiation was proven to be a suitable tool for CMCS hydrogel synthesis and could be of use in wound-healing therapy, as it may simultaneously sterilize the product.
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