材料科学
生物医学工程
纳米技术
伤口愈合
灵活性(工程)
电子皮肤
人体皮肤
伤口敷料
医学
外科
复合材料
统计
数学
生物
遗传学
作者
Xinhua Liu,Boqiang Cui,Xuechuan Wang,Manhui Zheng,Zhongxue Bai,Yu Ouyang,Yifan Fei,Huie Jiang
标识
DOI:10.1002/adhm.202202971
摘要
Electronic skins (e-skins) have the potential to turn into breakthroughs in biomedical applications. Herein, a novel acellular dermal matrix (ADM)-based bioelectronic skin (e-ADM) is used to fabricate versatile "wound therapy-health monitoring" tissue-nanoengineered skin scaffolds via a facile "one-pot" bio-compositing strategy to incorporate the conductive carbon nanotubes and self-assembled micro-copper oxide microspheres with a cicada-wing-like rough surface and nanocone microstructure. The e-ADM exhibits robust tensile strength (22 MPa), flexibility, biodegradability, electroactivity, and antibacterial properties. Interestingly, e-ADM exhibits the pH-responsive ability for intelligent command between sterilization and wound repair . Additionally, e-ADM enables accurate real-time monitoring of human activities, providing a novel flexible e-skin sensor to record injury and motions. In vitro and in vivo experiments show that with electrical stimulation, e-ADM could prominently facilitate cell growth and proliferation and further promote full-thickness skin wound healing, providing a comprehensive therapeutic strategy for smart sensing and tissue repair, guiding the development of high-performance "wound therapy-health monitoring" bioelectronic skin-scaffolds.
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