环加成
化学
重氮
催化作用
选择性
组合化学
金属
盐(化学)
药物化学
有机化学
作者
Wenli Song,Yunyun Liu,Nan Yan,Jie‐Ping Wan
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-03-22
卷期号:25 (12): 2139-2144
被引量:27
标识
DOI:10.1021/acs.orglett.3c00636
摘要
The three-component reactions of enaminones, α-diazo esters/ketones, and t-butyl nitrite (TBN) for the switchable synthesis of isomeric isoxazoles have been realized. The catalysis with Cu(II) salt provides 3,4-disubsituted isoxazoles via [3 + 2] cycloaddition. On the other hand, the catalysis of Ag(I) with identical substrates leads to isomeric isoxazoles with reversed C3 and C4 substitution based on a key [2 + 1] cycloaddition.
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